DE - SYNCHRONY THEORY

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                        DE - SYNCHRONY THEORY OF PUBERTY 

  • This theory is based on a finding that GnRH concentrations in the hypothalamus during prepuberty are comparable to those in the adult animals. 
  • GnRH from the hypothalamus is controlled by an area in the hypothalamus referred to as the neural GnRH pulse generator.   
  • Age related changes in brain morphology and neuronal cytoarchitecture may also be important.

Theory

  • Desynchrony theory proposes that the lack of GnRH stimulation of the pituitary in prepubertal animal is a result of the desynchronization of the discharge or 'firing' of the GnRH secreting neurons. 
  • This hypothesis has some support from in vitro studies in immortalized GnRH neurons.                                      

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