GONADOSTAT THEORY

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GONADOSTAT THEORY OF PUBERTY:

     The gonadostat theory was proposed by Hohlweg, 1931

    1. During prepuberty, sensitivity to the negative feedback actions of gonadal steroids is highest, resulting in a low release of GnRH and gonadotropins. 
    2. Initiation of puberty is secondary to a decrease in sensitivity to gonadal steroid feedback inhibition, resulting in increased GnRH and gonadotropin release, until a new equilibrium level is reached in adulthood.

Example:
       Failure of prepubertal ewe lamb to undergo ovulation and oestrus is due to the high threshold for the positive feedback is lowered, thus there is no LH surge. At puberty, the threshold is lowered, thus allowing the pituitary to respond.

Comments

  1. Unknown28 December 2018 at 00:41

    i thought this was proposed by Geoffrey Wingfield Harris 1913-1971 ?

    ReplyDelete
    Replies
    1. Elango29 December 2018 at 10:55

      Refer this sir

      https://pdfs.semanticscholar.org/0c9f/000b77612428af939a9f7d4c307355af823b.pdf

      Delete

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